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Nanoscale Radiation Engineering of Advanced Materials for Potential Biomedical Applications (F23028)

This CRP had a very strong impact on enhancing the research capabilities of the participating institutions in radiation engineering on the nanoscale, for the preparation/modification of new polymer materials intended for biomedical applications.

17 research institutions participated in this project (under 10 Research Contracts and 7 Agreements). Three Research Coordination Meetings (RCMs) were held with the 3rd one taking place prior to the International Symposium on Ionizing Radiations and Polymers (IRaP2012), one of the most important conferences in the radiation technology field, devoted to basic and applied polymer radiation sciences and technologies. By planning it this way, the participants of the RCM were given an opportunity to meet with leading scientists and discuss recent achievements in research and applications, and plan future projects and collaboration at such a high-level event.

The following achievements can be highlighted:
nanogels and nanoparticles based on natural and/or synthetic polymers and proteins were developed by a precise control of the structure, size, shape and functionality;
a number of developed nanocarriers were tested for drug delivery applications;
nanoporous membranes were successfully fabricated, functionalized and tested for drug delivery;
hydrogel-nanoparticle composites were developed for drug release, as drug-eluting coating for medical implant, and as coating with antimicrobial properties;
a multifunctional electrospun nanofiber network was produced and tested as sensor;
functional thermo-responsive materials for cell sheet engineering have been prepared and successfully tested for culturing a cell monolayer.

Under this CRP several institutions succeeded in starting the transfer of technology to industry. The participants established numerous collaborations and signed relevant agreements between their institutions that will be in effect long after this CRP is completed. Participants have also used additional IAEA support under national and regional TC projects to collaborate, and had also applied jointly for additional support of their work to various EU institutions. Additionally, the participants proposed several follow-up activities.

More than 100 publications and papers were issued during this CRP, where the multi-disciplinary uses of polymers can be recognized.

(a) Confocal microscopy of MC3T3-E1 cells incubated with PVP-graft-APMAM nanogels after 3h. Resumption of all mount, with an overall thickness of about 20 μm: (a1) green fluorescein-labeled nanoparticles, (a2) cells stained using ethidium bromide to visualize nuclei, (a3) the merger of (a1) and (a2) images.
(b) Localization of P*-g-A (100)FITC NGs in MC3T3-E1 cells. The histogram represents the amount of fluorescent nanoparticles present inside the MC3T3-E1 cells at different times (from 0 to 48 hr).
(c) Image of ECV304 endothelial cells incubated with red fluorescent (P*-g-AFITC)Ab-TRIC nanogels. F-actin marked with green fluorescent phalloidin, nuclei with DAPI. (Participant from Italy)

A snapshot microscope photograph illustrating temperature-triggered detachment of fibroblast cell layer from the radiation-synthesized PP-g-TMA surface. (Participant from Poland)

Click here for the project description.

Links to the reports of the 1st and 2nd RCM: